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In summary, our study provides the first evidence that ADAM family members can selectively regulate integrin-mediated cell migration. For example it seemed that if the expression level of ADAM33 is increased, it maintains its ability to inhibit α5β1 integrin-mediated cell migration, but loses it ability to inhibit α4β1-mediated cell migration (Huang, Brideges, and White, unpublished data). If ADAMs selectively titer integrin-mediated cell migration, they may do so in complex ways. For example, if cells in a population express multiple integrins that are capable of engaging multiple ECM substrates, the expression of an ADAM would not stop cell migration. Our finding that different ADAMs can selectively affect cell migration mediated by different integrins suggests that ADAMs could influence integrin-mediated migration events in interesting and complex ways.
ADAM12 Inhibits Integrin α4β1-mediated Random Cell Motility
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